Zincate‐Mediated Remote Functionalisation of <i>p</i> ‐Iodobenzyl Derivatives Through Metallotropy in 2‐Methyltetrahydrofuran as Key Solvent
نویسندگان
چکیده
2-MeTHF (2-methyltetrahydrofuran) promotes the zincate-mediated remote functionalisation of p-iodobenzyl derivatives through metallotropy with a broad scope. This biosourced solvent remarkably impacted all key elementary steps involved in tandem reaction. The method tolerates wide range sensitive functionalities within substrates as well enolisable and activated or deactivated aromatic aldehydes reaction partners. A challenging benzyl naphthalene derivative was even reacted an original dearomatisation/rearomatisation/metallotropy chain.
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2022
ISSN: ['1615-4169', '1615-4150']
DOI: https://doi.org/10.1002/adsc.202200475